Catalog No.: PC-70345Not For Human Use, Lab Use Only.
7,8-Dihydroxyflavone (7,8-DHF) is a naturally occurring flavone that has been found to act as a potent and selective agonist of TrkB with Kd of 320 nM.
7,8-Dihydroxyflavone (7,8-DHF) is a naturally occurring flavone that has been found to act as a potent and selective agonist of TrkB with Kd of 320 nM.
7,8-Dihydroxyflavone (7,8-DHF) demonstrates remarkable therapeutic efficacy in animal models of a variety of central nervous system disorders.
7,8-Dihydroxyflavone (7,8-DHF) also possess antiestrogenic and antiproliferative activities.
7,8-Dihydroxyflavone (7,8-DHF) orally bioavailable and able to penetrate the blood–brain barrier.
7,8-dihydroxyflavone (7,8-DHF) also is a direct and potent pyridoxal 5'-phosphate phosphatase (PDXP) inhibitor, an enzyme that controls levels of pyridoxal 5'-phosphate (PLP), the co-enzymatically active form of vitamin B6.
Physicochemical Properties
M.Wt
254.238
Formula
C15H10O4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
7,8-dihydroxy-2-phenyl-4H-chromen-4-one
References
1. English AW, et al. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16217-22.
2. Liu X, et al. J Med Chem. 2010 Dec 9;53(23):8274-86.
3. Le Bail JC, et al. Cancer Lett. 1998 Aug 14;130(1-2):209-16.
