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Chemical Structure : 7,8-Dihydroxyflavone
CAS No.: 38183-03-8
Catalog No.: PC-70345Not For Human Use, Lab Use Only.
7,8-Dihydroxyflavone (7,8-DHF) is a naturally occurring flavone that has been found to act as a potent and selective agonist of TrkB with Kd of 320 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $68 | In stock | |
| 100 mg | $98 | In stock | |
| 250 mg | $158 | In stock | |
| 1 g | Get quote |
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7,8-Dihydroxyflavone (7,8-DHF) is a naturally occurring flavone that has been found to act as a potent and selective agonist of TrkB with Kd of 320 nM.
7,8-Dihydroxyflavone (7,8-DHF) demonstrates remarkable therapeutic efficacy in animal models of a variety of central nervous system disorders.
7,8-Dihydroxyflavone (7,8-DHF) also possess antiestrogenic and antiproliferative activities.
7,8-Dihydroxyflavone (7,8-DHF) orally bioavailable and able to penetrate the blood–brain barrier.
7,8-dihydroxyflavone (7,8-DHF) also is a direct and potent pyridoxal 5'-phosphate phosphatase (PDXP) inhibitor, an enzyme that controls levels of pyridoxal 5'-phosphate (PLP), the co-enzymatically active form of vitamin B6.
| M.Wt | 254.238 | |
| Formula | C15H10O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
7,8-dihydroxy-2-phenyl-4H-chromen-4-one |
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1. English AW, et al. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16217-22.
2. Liu X, et al. J Med Chem. 2010 Dec 9;53(23):8274-86.
3. Le Bail JC, et al. Cancer Lett. 1998 Aug 14;130(1-2):209-16.
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