You are here:Home-Chemical Inhibitors & Agonists-Tyrosine Kinase-Trk Receptor-7,8-Dihydroxyflavone
7,8-Dihydroxyflavone

Chemical Structure : 7,8-Dihydroxyflavone

CAS No.: 38183-03-8

7,8-Dihydroxyflavone (7,8-DHF)

Catalog No.: PC-70345Not For Human Use, Lab Use Only.

7,8-Dihydroxyflavone (7,8-DHF) is a naturally occurring flavone that has been found to act as a potent and selective agonist of TrkB with Kd of 320 nM.

Packing Price Stock Quantity
50 mg $68 In stock
100 mg $98 In stock
250 mg $158 In stock
1 g Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

7,8-Dihydroxyflavone (7,8-DHF) is a naturally occurring flavone that has been found to act as a potent and selective agonist of TrkB with Kd of 320 nM.
7,8-Dihydroxyflavone (7,8-DHF) demonstrates remarkable therapeutic efficacy in animal models of a variety of central nervous system disorders.
7,8-Dihydroxyflavone (7,8-DHF) also possess antiestrogenic and antiproliferative activities.
7,8-Dihydroxyflavone (7,8-DHF) orally bioavailable and able to penetrate the blood–brain barrier.
7,8-dihydroxyflavone (7,8-DHF) also is a direct and potent pyridoxal 5'-phosphate phosphatase (PDXP) inhibitor, an enzyme that controls levels of pyridoxal 5'-phosphate (PLP), the co-enzymatically active form of vitamin B6.

Physicochemical Properties

M.Wt 254.238
Formula C15H10O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

7,8-dihydroxy-2-phenyl-4H-chromen-4-one

References

1. English AW, et al. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16217-22.

2. Liu X, et al. J Med Chem. 2010 Dec 9;53(23):8274-86.

3. Le Bail JC, et al. Cancer Lett. 1998 Aug 14;130(1-2):209-16.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: