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709W92

Chemical Structure : 709W92

CAS No.: 163239-23-4

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709W92

Catalog No.: PC-49665Not For Human Use, Lab Use Only.

709W92 is a small molecule inhibitor of both tryptophan 2,3-dioxygenase (TDO) and 5-hydroxytryptamine (5-HT) reuptake, shows antidepressant efficacy.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    709W92 is a small molecule inhibitor of both tryptophan 2,3-dioxygenase (TDO) and 5-hydroxytryptamine (5-HT) reuptake, shows antidepressant efficacy.
    709W92 potentiated head-twitch produced by 5-hydroxytryptophan, prevented head-twitch and whole brain 5-HT depletion produced by p-chloroamphetamine and rapidly decreased dorsal raphe firing.
    709W92 showed anxiolytic activity in the rat-pup vocalization model of anxiety in vivo.

    Physicochemical Properties

    M.Wt 238.27
    Formula C15H11FN2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (E)-6-fluoro-3-[2-(4-pyridyl)vinyl]-1H-indole

    References

    1. Salter M, et al. Neuropharmacology. 1995 Feb;34(2):217-27.

    2. Salter M, et al. Adv Exp Med Biol. 1996;398:61-5.

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