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Chemical Structure : 7HP349
Catalog No.: PC-38811Not For Human Use, Lab Use Only.
Alintegimod (7HP349) is a small molecule activator of the integrins αLβ2 (LFA-1) and α4β1 (VLA-4). 7HP349 directly activates integrin cell adhesion receptors crucial for the generation of an immune response.
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Alintegimod (7HP349) is a small molecule activator of the integrins αLβ2 (LFA-1) and α4β1 (VLA-4). 7HP349 directly activates integrin cell adhesion receptors crucial for the generation of an immune response.
7HP349 increases tumor-specific T cell activation and localization to a non-T cell inflamed cold tumor microenvironment typically characterized by low ICAM-1 expression and enhances the anti-tumor activity of CTLA-4 and PD-1/L1.
7HP349 monotherapy had modest effects on anti- programmed death 1 (PD-1)-resistant tumors, whereas combinatorial treatment with anti- T-lymphocyte-associated protein 4 (CTLA-4) therapy increased CD8+ Teff intratumoral sequestration and synergized in inducing cancer regression, in cooperation with neutrophils.
| M.Wt | 620.812 | |
| Formula | C28H32N2O6S4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hickman A, et al. J Clin Invest. 2022 May 12:e154152.
2. Lokugamage N, et al. NPJ Vaccines. 2021 Sep 8;6(1):114.
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