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7HP349

Chemical Structure : 7HP349

CAS No.: 1378535-08-0

7HP349 (Alintegimod)

Catalog No.: PC-38811Not For Human Use, Lab Use Only.

Alintegimod (7HP349) is a small molecule activator of the integrins αLβ2 (LFA-1) and α4β1 (VLA-4). 7HP349 directly activates integrin cell adhesion receptors crucial for the generation of an immune response.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Alintegimod (7HP349) is a small molecule activator of the integrins αLβ2 (LFA-1) and α4β1 (VLA-4). 7HP349 directly activates integrin cell adhesion receptors crucial for the generation of an immune response.
    7HP349 increases tumor-specific T cell activation and localization to a non-T cell inflamed cold tumor microenvironment typically characterized by low ICAM-1 expression and enhances the anti-tumor activity of CTLA-4 and PD-1/L1.
    7HP349 monotherapy had modest effects on anti- programmed death 1 (PD-1)-resistant tumors, whereas combinatorial treatment with anti- T-lymphocyte-associated protein 4 (CTLA-4) therapy increased CD8+ Teff intratumoral sequestration and synergized in inducing cancer regression, in cooperation with neutrophils.

    Physicochemical Properties

    M.Wt 620.812
    Formula C28H32N2O6S4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(bis(thiophen-2-ylmethyl)carbamate)

    References

    1. Hickman A, et al. J Clin Invest. 2022 May 12:e154152.

    2. Lokugamage N, et al. NPJ Vaccines. 2021 Sep 8;6(1):114.

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