Catalog No.: PC-42226Not For Human Use, Lab Use Only.
8-Nitrotryptanthrin (GNF-PF-3777) is a potent human indoleamine 2,3-dioxygenase 2 (IDO2) inhibitor with Ki of 0.97 uM, also exhibits significant antitrypanosomal activities with EC50 of 0.82 uM.
8-Nitrotryptanthrin (GNF-PF-3777) is a potent human indoleamine 2,3-dioxygenase 2 (IDO2) inhibitor with Ki of 0.97 uM, also exhibits significant antitrypanosomal activities with EC50 of 0.82 uM.
Physicochemical Properties
M.Wt
293.2338
Formula
C15H7N3O4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: 6.4 mg/mL (Need warming)
Chemical Name/SMILES
Indolo[2,1-b]quinazoline-6,12-dione, 8-nitro-
References
1. Li J, et al. Eur J Med Chem. 2016 Nov 10;123:171-179.
2. Scovill J, et al. Antimicrob Agents Chemother. 2002 Mar;46(3):882-3.
3. Hwang JM, et al. J Nat Prod. 2013 Mar 22;76(3):354-67.
