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Chemical Structure : A-1155463
CAS No.: 1235034-55-5
Catalog No.: PC-45687Not For Human Use, Lab Use Only.
A-1155463 is a highly potent and selective BCL-XL inhibitor (Ki=10 pM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $178 | In stock | |
| 25 mg | $288 | In stock | |
| 100 mg | $658 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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A-1155463 is a highly potent and selective BCL-XL inhibitor (Ki=10 pM).
A-1155463 shows >1000-fold weaker binding to BCL-2, BCL-W (Ki =19 nM) and MCL-1 (Ki >440 nM).
A-1155463 inhibits H146 SCLC xenograft tumor growth in vivo.
| M.Wt | 669.7881 | |
| Formula | C35H32FN5O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
4-Thiazolecarboxylic acid, 2-[8-[(2-benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-5-[3-[4-[3-(dimethylamino)-1-propyn-1-yl]-2-fluorophenoxy]propyl]- |
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1. Tao ZF, et al. ACS Med Chem Lett. 2014 Aug 26;5(10):1088-93.
2. Leverson JD, et al. Sci Transl Med. 2015 Mar 18;7(279):279ra40.
3. Punnoose EA, et al. Mol Cancer Ther. 2016 May;15(5):1132-44.
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