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Chemical Structure : A-1210477
CAS No.: 1668553-26-1
Catalog No.: PC-43048Not For Human Use, Lab Use Only.
A-1210477 is a potent, selective Mcl-1 inhibitor that bind to Mcl-1 (Ki=0.45 nM) to disrupt MCL-1-BIM complexes, shows much weaker against Bcl-2 (Ki=132 nM) and Bcl-XL (Ki>660 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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A-1210477 is a potent, selective Mcl-1 inhibitor that bind to Mcl-1 (Ki=0.45 nM) to disrupt MCL-1-BIM complexes, shows much weaker against Bcl-2 (Ki=132 nM) and Bcl-XL (Ki>660 nM).
A-1210477 induces the hallmarks of intrinsic apoptosis and demonstrates single agent killing of multiple myeloma and non-small cell lung cancer cell lines.
A-1210477 synergizes with the BCL-2/BCL-XL inhibitor navitoclax to kill a variety of cancer cell lines.
A-1210477 also enhances cobimetinib-induced apoptosis in vitro.
| M.Wt | 850.0366 | |
| Formula | C46H55N7O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: < 4.8 mg/mL |
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| Chemical Name/SMILES |
1H-Indole-2-carboxylic acid, 7-[5-[[4-[4-[(dimethylamino)sulfonyl]-1-piperazinyl]phenoxy]methyl]-1,3-dimethyl-1H-pyrazol-4-yl]-1-[2-(4-morpholinyl)ethyl]-3-[3-(1-naphthalenyloxy)propyl]- |
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1. Leverson JD, et al. Cell Death Dis. 2015 Jan 15;6:e1590.
2. Xiao Y, et al. Mol Cancer Ther. 2015 Aug;14(8):1837-47.
3. Phillips DC, et al. Blood Cancer J. 2015 Nov 13;5:e368.
4. Karpel-Massler G, et al. Cancer Res. 2017 Jul 1;77(13):3513-3526.
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