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Chemical Structure : A-1331852
CAS No.: 1430844-80-6
Catalog No.: PC-45700Not For Human Use, Lab Use Only.
A-1331852 (A1331852) is a potent and selective BCL-XL inhibitor (Ki<10 pM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $248 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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A-1331852 (A1331852) is a potent and selective BCL-XL inhibitor (Ki<10 pM).
A-1331852 shows much weaker affinity for BCL-2 (Ki=6 nM), BCL-W (Ki=4 nM), and MCL-1 (Ki=142 nM).
A-1331852 selectively disrupts BCL-XL–BIM complexes and induces the hallmarks of apoptosis in BCL-XL–dependent Molt-4 cells (Molt-4 viability IC50=6 nM).
A-1331852 demonstrates antitumor efficacy in the Molt-4 xenograft model; orally active.
| M.Wt | 658.8117 | |
| Formula | C38H38N6O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 12 mg/mL |
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| Chemical Name/SMILES |
2-Pyridinecarboxylic acid, 6-[8-[(2-benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazol-4-yl]- |
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1. Leverson JD, et al. Sci Transl Med. 2015 Mar 18;7(279):279ra40.
2. Punnoose EA, et al. Mol Cancer Ther. 2016 May;15(5):1132-44.
3. Lucas CM, et al. Leukemia. 2016 Jun;30(6):1273-81.
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