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Chemical Structure : A-134974
Catalog No.: PC-38794Not For Human Use, Lab Use Only.
A-134974 is a potent and selective adenosine kinase (AdK) inhibitor with IC50 of 60 pM.
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A-134974 is a potent and selective adenosine kinase (AdK) inhibitor with IC50 of 60 pM.
Systemic A-134974 (i.p.) dose dependently reduced hyperalgesia (ED(50) = 1 micromol/kg) and at higher doses, reduced locomotor activity (ED(50) = 16 micromol/kg).
A-134974 relieves tactile allodynia via spinal sites of action in peripheral nerve injured rats.
| M.Wt | 375.17 | |
| Formula | C11H14IN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. McGaraughty S, et al. J Pharmacol Exp Ther. 2001 Feb;296(2):501-9.
2. Zhu CZ, et al. Brain Res. 2001 Jun 29;905(1-2):104-10.
3. Wang H, et al. J Virol. 2005 Jun;79(12):7410-8.
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