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A-134974

Chemical Structure : A-134974

CAS No.: 186141-75-3

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A-134974 (A134974)

Catalog No.: PC-38794Not For Human Use, Lab Use Only.

A-134974 is a potent and selective adenosine kinase (AdK) inhibitor with IC50 of 60 pM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    A-134974 is a potent and selective adenosine kinase (AdK) inhibitor with IC50 of 60 pM.
    Systemic A-134974 (i.p.) dose dependently reduced hyperalgesia (ED(50) = 1 micromol/kg) and at higher doses, reduced locomotor activity (ED(50) = 16 micromol/kg).
    A-134974 relieves tactile allodynia via spinal sites of action in peripheral nerve injured rats.

    Physicochemical Properties

    M.Wt 375.17
    Formula C11H14IN5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1S,2R,3S,5R)-3-amino-5-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol

    References

    1. McGaraughty S, et al. J Pharmacol Exp Ther. 2001 Feb;296(2):501-9.

    2. Zhu CZ, et al. Brain Res. 2001 Jun 29;905(1-2):104-10.

    3. Wang H, et al. J Virol. 2005 Jun;79(12):7410-8.

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