A-317567 |CAS:371217-32-2 Probechem Biochemicals

Chemical Structure : A-317567

A-317567 (A317567)

Catalog No.: PC-60005Not For Human Use, Lab Use Only.

A-317567 (A317567) is a novel potent acid sensing ion channel (ASIC) blocker with IC50 of 2-30 uM.

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Biological Activity

A-317567 (A317567) is a novel potent acid sensing ion channel (ASIC) blocker with IC50 of 2-30 uM; inhibits pH 4.5-evoked ASIC currents, also equipotently blocks the sustained phase of ASIC3-like current; is more potent than amiloride in vitro and in vivo pain models, with minimal brain penetration.

Pain

Discontinued

Physicochemical Properties

M.Wt	397.566
Formula	C27H31N3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-{2-[2-methyl-1-(propan-2-yl)-1,2,3,4-tetrahydroisoquinolin-7-yl]cyclopropyl}naphthalene-2-carboximidamide

References

1. Dubé GR, et al. Pain. 2005 Sep;117(1-2):88-96.

2. Hayes SG, et al. Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1720-5.

3. Dwyer JM, et al. Psychopharmacology (Berl). 2009 Mar;203(1):41-52.

4. Kuduk SD, et al. ACS Chem Neurosci. 2010 Jan 20;1(1):19-24.

A-317567 (A317567)

Biological Activity

Physicochemical Properties

References

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