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Chemical Structure : A-317567
Catalog No.: PC-60005Not For Human Use, Lab Use Only.
A-317567 (A317567) is a novel potent acid sensing ion channel (ASIC) blocker with IC50 of 2-30 uM.
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A-317567 (A317567) is a novel potent acid sensing ion channel (ASIC) blocker with IC50 of 2-30 uM; inhibits pH 4.5-evoked ASIC currents, also equipotently blocks the sustained phase of ASIC3-like current; is more potent than amiloride in vitro and in vivo pain models, with minimal brain penetration.
Pain
Discontinued
| M.Wt | 397.566 | |
| Formula | C27H31N3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dubé GR, et al. Pain. 2005 Sep;117(1-2):88-96.
2. Hayes SG, et al. Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1720-5.
3. Dwyer JM, et al. Psychopharmacology (Berl). 2009 Mar;203(1):41-52.
4. Kuduk SD, et al. ACS Chem Neurosci. 2010 Jan 20;1(1):19-24.
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