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A-745

Chemical Structure : A-745

CAS No.: 2911639-60-4

A-745 (A745)

Catalog No.: PC-72303Not For Human Use, Lab Use Only.

A-745 (A745) is a selective and potent HPK1 chemical probe (inhibitor) of HPK1 (MAP4K1) with IC50 of 4 nM.

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    Biological Activity

    A-745 (A745) is a selective and potent HPK1 chemical probe (inhibitor) of HPK1 (MAP4K1) with IC50 of 4 nM.
    A-745 demonstrates an excellent cellular selectivity binding profile within pharmacologically relevant concentrations in unbiased cellular kinase-binding assays.
    A-745 exhibited in vitro immune cell activation phenotype reminiscent of Hpk1-deficient and Hpk1-kinase-dead T cells, including augmented proliferation and cytokine production.
    A-745 is a selective and potent small molecule HPK1 inhibitors with the pharmacological properties for immunotherapy.

    Physicochemical Properties

    M.Wt 417.473
    Formula C22H23N7O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (R)-6-(5-benzamidocyclohex-1-en-1-yl)-3-((1-methyl-1H-pyrazol-4-yl)amino)pyrazine-2-carboxamide

    References

    1. Sven Malchow, et al. ACS Chem Biol. 2022 Feb 21.

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