A-745 | HPK1 inhibitor | Probechem Biochemicals

Chemical Structure : A-745

A-745 (A745)

Catalog No.: PC-72303Not For Human Use, Lab Use Only.

A-745 (A745) is a selective and potent HPK1 chemical probe (inhibitor) of HPK1 (MAP4K1) with IC50 of 4 nM.

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Biological Activity

A-745 (A745) is a selective and potent HPK1 chemical probe (inhibitor) of HPK1 (MAP4K1) with IC50 of 4 nM.
A-745 demonstrates an excellent cellular selectivity binding profile within pharmacologically relevant concentrations in unbiased cellular kinase-binding assays.
A-745 exhibited in vitro immune cell activation phenotype reminiscent of Hpk1-deficient and Hpk1-kinase-dead T cells, including augmented proliferation and cytokine production.
A-745 is a selective and potent small molecule HPK1 inhibitors with the pharmacological properties for immunotherapy.

Physicochemical Properties

M.Wt	417.473
Formula	C22H23N7O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-6-(5-benzamidocyclohex-1-en-1-yl)-3-((1-methyl-1H-pyrazol-4-yl)amino)pyrazine-2-carboxamide

References

1. Sven Malchow, et al. ACS Chem Biol. 2022 Feb 21.

A-745 (A745)

Biological Activity

Physicochemical Properties

References

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