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A-770041

Chemical Structure : A-770041

CAS No.: 869748-10-7

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A-770041 (A770041;A 770041)

Catalog No.: PC-42786Not For Human Use, Lab Use Only.

A-770041 (A770041) is a potent and selective small-molecule inhibitor of Lck kinase with IC50 of 147 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    A-770041 (A770041) is a potent and selective small-molecule inhibitor of Lck kinase with IC50 of 147 nM.
    A-770041 shows 60-fold selective against Src, 95-fold selective against Fgr and 300-fold selective against Fyn.
    A-770041 inhibits anti-CD3 induced IL-2 with EC50 of 80 nM; orally bioavailable.

    Physicochemical Properties

    M.Wt 621.7319
    Formula C34H39N9O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1H-Indole-2-carboxamide, N-[4-[1-[trans-4-(4-acetyl-1-piperazinyl)cyclohexyl]-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-1-methyl-

    References

    1. Stachlewitz RF, et al. J Pharmacol Exp Ther. 2005 Oct;315(1):36-41.

    2. Burchat A, et al. Bioorg Med Chem Lett. 2006 Jan 1;16(1):118-22.

    3. Duan Z, et al. BMC Cancer. 2014 Sep 19;14:681.

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