A-803467 (A803467) is a potent and selective Nav1.8 sodium channel blocker with IC50 of 8 nM.
A-803467 displays >100-fold selectivity versus human Nav1.2, Nav1.3, Nav1.5, and Nav1.7 (IC50s>1 uM).
A-803467 potently blocks tetrodotoxin-resistant currents (IC50= 140 nM) and the generation of spontaneous and electrically evoked action potentials in vitro in rat dorsal root ganglion neurons.
A-803467 attenuates neuropathic and inflammatory pain in the rat.
