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Chemical Structure : A-867744
CAS No.: 1000279-69-5
Catalog No.: PC-42900Not For Human Use, Lab Use Only.
A-867744 is a potent, selective α7 nAChR positive allosteric modulator (PAM) with Ki of 23 nM, potentiates acetylcholine (ACh)-evoked currents with EC50 of 1 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 25 mg | $228 | In stock | |
| 100 mg | $498 | In stock | |
| 500 mg | Get quote |
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A-867744 is a potent, selective α7 nAChR positive allosteric modulator (PAM) with Ki of 23 nM, potentiates acetylcholine (ACh)-evoked currents with EC50 of 1 uM; A-867744 failed to potentiate responses mediated by 5-HT3A or α3β4 and α4β2 nAChRs; increases choline-evoked α7 currents and recovery from inhibition/desensitization, and enhances spontaneous inhibitory postsynaptic current activity at 10 uM in rat hippocampus; normalizes gating deficits in rodent model of sensory gating.
| M.Wt | 402.8945 | |
| Formula | C20H19ClN2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzenesulfonamide, 4-[5-(4-chlorophenyl)-2-methyl-3-(1-oxopropyl)-1H-pyrrol-1-yl]- |
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1. Malysz J, et al. J Pharmacol Exp Ther. 2009 Jul;330(1):257-67.
2. Faghih R, et al. J Med Chem. 2009 May 28;52(10):3377-84.
3. Hu M, et al. Br J Pharmacol. 2009 Dec;158(8):1857-64.
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