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A-908292

Chemical Structure : A-908292

CAS No.: 903886-95-3

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A-908292 (A 908292)

Catalog No.: PC-73297Not For Human Use, Lab Use Only.

A-908292 is a highly potent and selective acetyl-CoA carboxylase 2 (ACC2) inhibitor with IC50 of 38 nM (hACC2), no activity against ACC1 (IC50>30 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A-908292 is a highly potent and selective acetyl-CoA carboxylase 2 (ACC2) inhibitor with IC50 of 38 nM (hACC2), no activity against ACC1 (IC50>30 uM).

Physicochemical Properties

M.Wt 360.428
Formula C18H20N2O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Carbamic acid, N-[(1S)-1-methyl-3-[2-[4-(1-methylethoxy)phenoxy]-5-thiazolyl]-2-propyn-1-yl]-, methyl ester

References

1. Nishiura Y, et al. Bioorg Med Chem Lett. 2018 Aug 1;28(14):2498-2503.

2. Takagi H, et al. J Pharmacol Exp Ther. 2020 Mar;372(3):256-263.

3. Waring JF, et al. J Pharmacol Exp Ther. 2008 Feb;324(2):507-16.

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