Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
EN | CN

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Tyrosine Kinase-TAM Receptor (Tyro3-Axl-Mer)-A-910
A-910

Chemical Structure : A-910

CAS No.: 3036009-40-9

Add to Favorites

A-910 (A910)

Catalog No.: PC-23041Not For Human Use, Lab Use Only.

A-910 is a highly potent and selective, orally active dual MerTK/Axl inhibitor with IC50 of 0.2/0.9 nM respectively, >200-fold selective over Tyro3.

Packing Price Stock Quantity
50 mg Get quote
100 mg Get quote
250 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A-910 is a highly potent and selective, orally active dual MerTK/Axl inhibitor with IC50 of 0.2/0.9 nM respectively, >200-fold selective over Tyro3.
A-910 exhibits similar biochemical and Ba/F3 cellular potency (IC50=4.2 nM), shows EC50 of 4.0 and 8.0 nM in in vitro efferocytosis and pMerTK assays respectively.
A-910 exhibits favorable oral bioavailability, exceptional kinome selectivity, and significantly improved in vivo target engagement.

Physicochemical Properties

M.Wt 694.85
Formula C40H47FN6O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-Amino-N-[(1S,2S)-2-({4-[(5S)-5-{4-[(2S)-2,3-dihydroxypropyl]piperazin-1-yl}-5,6,7,8-tetrahydronaphthalen-2-yl]phenyl}methoxy)cyclopentyl]-2′-fluoro[3,3′-bipyridine]-5-carboxamide

References

1. Yu Y, et al. J Med Chem. 2024 Sep 16. doi: 10.1021/acs.jmedchem.4c01450.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: