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A-943931

Chemical Structure : A-943931

CAS No.: 1027330-97-7

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A-943931 (A943931 )

Catalog No.: PC-63420Not For Human Use, Lab Use Only.

A-943931 is a potent, selective antagonist of histamine H4 receptor (H4R) with binding pKi of 8.33 and 8.42 for hH4 and rH4, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    A-943931 is a potent, selective antagonist of histamine H4 receptor (H4R) with binding pKi of 8.33 and 8.42 for hH4 and rH4, respectively.
    A-943931 displays >150-fold selectivity over H1, H2 and H3 receptors.
    A-943931 potently inhibits zymosan-induced peritonitis in mice with ED50 of 34 umol/kg.

    Physicochemical Properties

    M.Wt 295.39
    Formula C17H21N5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-((3R)-3-amino-pyrrolidin-1-yl)-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidin-2-ylamine

    References

    1. Cowart MD, et al. J Med Chem. 2008 Oct 23;51(20):6547-57.

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