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Chemical Structure : A-943931
Catalog No.: PC-63420Not For Human Use, Lab Use Only.
A-943931 is a potent, selective antagonist of histamine H4 receptor (H4R) with binding pKi of 8.33 and 8.42 for hH4 and rH4, respectively.
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A-943931 is a potent, selective antagonist of histamine H4 receptor (H4R) with binding pKi of 8.33 and 8.42 for hH4 and rH4, respectively.
A-943931 displays >150-fold selectivity over H1, H2 and H3 receptors.
A-943931 potently inhibits zymosan-induced peritonitis in mice with ED50 of 34 umol/kg.
| M.Wt | 295.39 | |
| Formula | C17H21N5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cowart MD, et al. J Med Chem. 2008 Oct 23;51(20):6547-57.
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