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A-966492

Chemical Structure : A-966492

CAS No.: 934162-61-5

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A-966492 (A966492;A 966492)

Catalog No.: PC-42678Not For Human Use, Lab Use Only.

A-966492 (A966492) is a highly potent and efficacious PARP inhibitor with Ki/EC50 of 1 nM/1 nM for PARP-1.

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5 mg $128 In stock
10 mg $198 In stock
25 mg $348 In stock
50 mg $558 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A-966492 (A966492) is a highly potent and efficacious PARP inhibitor with Ki/EC50 of 1 nM/1 nM for PARP-1, Ki of 1.5 nM for PARP-2.
A-966492 exhibits orally bioavailable across multiple species, crosses the blood-brain barrier, and appears to distribute into tumor tissue.
A-966492 demonstrates good in vivo efficacy in a B16F10 subcutaneous murine melanoma model.

Physicochemical Properties

M.Wt 324.3522
Formula C18H17FN4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1H-Benzimidazole-7-carboxamide, 2-[2-fluoro-4-[(2S)-2-pyrrolidinyl]phenyl]-

References

1. Penning TD, et al. J Med Chem. 2010 Apr 22;53(8):3142-53.

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