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Chemical Structure : A16B1
Catalog No.: PC-22507Not For Human Use, Lab Use Only.
A16B1 is a specfic, allosteric inhibitor of the PhoQ histidine kinase, selectively inhibits the activity of the Salmonella PhoP/PhoQ system, blocks Salmonella pathogenicity.
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A16B1 is a specfic, allosteric inhibitor of the PhoQ histidine kinase, selectively inhibits the activity of the Salmonella PhoP/PhoQ system, blocks Salmonella pathogenicity.
A16B1 shows no activity against EnvZ/OmpR, CpxA/CpxR, PmrA/PmrB and Rcs TCS.
A16B1 inhibits the PhoP/PhoQ system by acting on the PhoQ domain that encompasses the second transmembrane region of the protein, negatively regulating its kinase activity.
A16B1 the antimicrobial peptide colistin shows a 4-fold reduction in its minimum inhibitory concentration (MIC) value when it is combined with A16B1.
A16B1 exhibits anti-virulence properties by decreasing Salmonella intramacrophage replication and increasing the survival of Galleria mellonella larvae, a complete multicellular organism model organism for the analysis of Salmonella systemic infections.
| M.Wt | 230.29 | |
| Formula | C12H10N2OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Carlos A Lobertti, et al. J Antimicrob Chemother. 2024 Jun 10:dkae151.
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