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Chemical Structure : A1899
Catalog No.: PC-20697Not For Human Use, Lab Use Only.
A1899 (A-1899) is a potent and highly selective blocker of the K(2P) channel TASK-1, selectively blocks human TASK-1 channels expressed in Xenopus oocytes with IC50 of 35.1 nM.
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A1899 (A-1899) is a potent and highly selective blocker of the K(2P) channel TASK-1, selectively blocks human TASK-1 channels expressed in Xenopus oocytes with IC50 of 35.1 nM.
A1899 has IC50 of 7 nM for TASK-1 channels expressed in CHO cells, 10-fold selectivity over TASK-3 channel.
A1899 also displays high selectivity over different potassium channels in Xenopus oocytes.
A1899 interacts with the M2 and M4 transmembrane segments of TASK-1 channels.
A1899 inhibits TASK-1 channels expressed in human and rodent alpha-cells.
| M.Wt | 500.55 | |
| Formula | C30H26F2N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Streit AK, et al. J Biol Chem. 2011;286:13977.
2. Schiekel J, et al. Cardiovasc Res. 2013 Jan 1;97(1):97-105.
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