Chemical Structure : A1899
CAS No.:
498577-46-1
A1899
(A-1899)
Catalog No.: PC-20697Not For Human Use, Lab Use Only.
A1899 (A-1899) is a potent and highly selective blocker of the K(2P) channel TASK-1, selectively blocks human TASK-1 channels expressed in Xenopus oocytes with IC50 of 35.1 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
A1899 (A-1899) is a potent and highly selective blocker of the K(2P) channel TASK-1, selectively blocks human TASK-1 channels expressed in Xenopus oocytes with IC50 of 35.1 nM.
A1899 has IC50 of 7 nM for TASK-1 channels expressed in CHO cells, 10-fold selectivity over TASK-3 channel.
A1899 also displays high selectivity over different potassium channels in Xenopus oocytes.
A1899 interacts with the M2 and M4 transmembrane segments of TASK-1 channels.
A1899 inhibits TASK-1 channels expressed in human and rodent alpha-cells.
Physicochemical Properties
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M.Wt
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500.55
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Formula
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C30H26F2N2O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C(C1=CC=CC=C1C2=CC=CC=C2CNC(CC3=CC=C(OC)C=C3)=O)NCC4=CC=C(F)C=C4F
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References
1. Streit AK, et al. J Biol Chem. 2011;286:13977.
2. Schiekel J, et al. Cardiovasc Res. 2013 Jan 1;97(1):97-105.
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