Catalog No.: PC-22020Not For Human Use, Lab Use Only.
A-71623 (A71623) is a cholecystokinin tetrapeptide (30-33) analogue as potent, highly selective CCK-A (CCK1) cholecystokinin receptor agonist with binding IC50 of 3.7 nM, >1000-fold selective over CCK-B receptor.
A-71623 (A71623) is a cholecystokinin tetrapeptide (30-33) analogue as potent, highly selective CCK-A (CCK1) cholecystokinin receptor agonist with binding IC50 of 3.7 nM, >1000-fold selective over CCK-B receptor. A-71623 exhibits IC50 values for A-71623 and A-70874 were 3.7 and 4.9 nM in guinea pig pancreas (CCK-A) and 4500 and 710 nM in cerebral cortex (CCK-B), respectively, in radioligand binding assays. In daily injection studies, the anorectic activity of CCK-8 diminished rapidly, whereas the suppressant effects of A71623 on food intakes and body weight gains persisted throughout the 11-day treatment period. A71623 reduced the spontaneous locomotor activity of rats at doses above those required to suppress intakes.
