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Chemical Structure : A71623
CAS No.: 130408-77-4
Catalog No.: PC-22020Not For Human Use, Lab Use Only.
A-71623 (A71623) is a cholecystokinin tetrapeptide (30-33) analogue as potent, highly selective CCK-A (CCK1) cholecystokinin receptor agonist with binding IC50 of 3.7 nM, >1000-fold selective over CCK-B receptor.
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|---|---|---|---|
| 2 mg | $398 | In stock | |
| 5 mg | $598 | In stock | |
| 10 mg | $958 | In stock | |
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A-71623 (A71623) is a cholecystokinin tetrapeptide (30-33) analogue as potent, highly selective CCK-A (CCK1) cholecystokinin receptor agonist with binding IC50 of 3.7 nM, >1000-fold selective over CCK-B receptor.
A-71623 exhibits IC50 values for A-71623 and A-70874 were 3.7 and 4.9 nM in guinea pig pancreas (CCK-A) and 4500 and 710 nM in cerebral cortex (CCK-B), respectively, in radioligand binding assays.
In daily injection studies, the anorectic activity of CCK-8 diminished rapidly, whereas the suppressant effects of A71623 on food intakes and body weight gains persisted throughout the 11-day treatment period.
A71623 reduced the spontaneous locomotor activity of rats at doses above those required to suppress intakes.
| M.Wt | 840.98 | |
| Formula | C44H56N8O9 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophyl-N6-[[(2-methylphenyl)amino]carbonyl]-L-lysyl-L-α-aspartyl-Nα-methyl-L-phenylalaninamide |
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1. Lin CW, et al. Mol Pharmacol. 1991 Mar;39(3):346-51.
2. Asin KE, et al. Am J Physiol. 1992 Jul;263(1 Pt 2):R125-35.
3. Asin KE, et al. Pharmacol Biochem Behav. 1992 Aug;42(4):699-704.
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