Chemical Structure : A8-A2
CAS No.:
709004-04-6
A8-A2
(PRRS NendoU inhibitor)
Catalog No.: PC-23811Not For Human Use, Lab Use Only.
A8-A2 is a specific small molecule inhibitor of PRRSV NSP11 nidoviral uridylate-specific endoribonuclease (NendoU) domain, shows broad-spectrum antiviral avitivity against nidoviruses.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
A8-A2 is a specific small molecule inhibitor of PRRSV NSP11 nidoviral uridylate-specific endoribonuclease (NendoU) domain, shows broad-spectrum antiviral avitivity against nidoviruses.
A8-A2 shows inhibitory effects on both VR- and LY-NSP11 activities at a concentration of 15 µM, with IC50 of 23.0 and 24.6 µM for LY- and VR-NSP11, respectively, in the NendoU assay at 2 h.
A8-A2 (30 uM, 50 uM) significantly reduced PRRSV RNA levels across all five strains with EC90 values of 10.00-17.92 µM.
A8-A2 exhibits a broad-spectrum antiviral agent against nidoviruses, supporting its therapeutic application for infections beyond PRRSV.
A8-A2 not only inhibits direct viral replication but also reactivates the cellular IFN-I response through the inhibition of NendoU activity.
The antiviral activity of A8-A2 is independent of mRNA splicing inhibition.
Physicochemical Properties
|
M.Wt
|
325.37
|
|
Formula
|
C17H19N5O2
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
5-ethyl-2-((7-methoxy-4-methylquinazolin-2-yl)amino)-6-methylpyrimidin-4(3H)-one
|
References
1. Zhu J, et al. J Virol. 2024 Dec 31:e0203424.
Contact Us
sales@probechem.com
