AAE871 | FLT3 inhibitor | Probechem Biochemicals

Chemical Structure : AAE871

AAE871 (AAE 871, AAE-871)

Catalog No.: PC-35272Not For Human Use, Lab Use Only.

AAE871 (AAE-871) is a potent type I kinase inhibitor of FLT3 with IC50 of 34 nM, potently inhibits proliferation of FLT3-ITD- and D835Y-expressing cells (IC50<10 nM) through selective inhibition of FLT3 kinase activity.

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Biological Activity

AAE871 (AAE-871) is a potent type I kinase inhibitor of FLT3 with IC50 of 34 nM, potently inhibits proliferation of FLT3-ITD- and D835Y-expressing cells (IC50<10 nM) through selective inhibition of FLT3 kinase activity.

Physicochemical Properties

M.Wt	498.65
Formula	C24H34N8O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N2-((1r,4r)-4-aminocyclohexyl)-9-ethyl-N6-(4-(piperidin-1-ylsulfonyl)phenyl)-9H-purine-2,6-diamine

References

1. Weisberg E, et al. Genes Cancer. 2010 Oct;1(10):1021-32.

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AAE871 (AAE 871, AAE-871)

Biological Activity

Physicochemical Properties

References

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