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Chemical Structure : AAK1 inhibitor (S)-31
Catalog No.: PC-20650Not For Human Use, Lab Use Only.
AAK1 inhibitor (S)-31 is a potent, selective and brain penetrant adaptor protein 2-associated kinase 1 (AAK1) inhibitor with IC50 of 5.8 nM.
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AAK1 inhibitor (S)-31 is a potent, selective and brain penetrant adaptor protein 2-associated kinase 1 (AAK1) inhibitor with IC50 of 5.8 nM.
AAK1 inhibitor (S)-31 displays 25-fold selectivity over BIKE (IC50 = 0.161 uM), and good kinase selectivity against in-house panel of kinases.
AAK1 inhibitor (S)-31 (30 mg/kg, sc) effectively reduced μ2 phosphorylation in C57BL6 mice.
AAK1 inhibitor (S)-31 exhibited improved enzyme and cellular potency compared to BMS-911172.
| M.Wt | 316.41 | |
| Formula | C20H20N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Richard A Hartz, et al. J Med Chem. 2022 Mar 10;65(5):4121-4155.
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