AAK1 inhibitor (S)-31

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Chemical Structure : AAK1 inhibitor (S)-31

Catalog No.: PC-20650Not For Human Use, Lab Use Only.

AAK1 inhibitor (S)-31 is a potent, selective and brain penetrant adaptor protein 2-associated kinase 1 (AAK1) inhibitor with IC50 of 5.8 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AAK1 inhibitor (S)-31 is a potent, selective and brain penetrant adaptor protein 2-associated kinase 1 (AAK1) inhibitor with IC50 of 5.8 nM.
AAK1 inhibitor (S)-31 displays 25-fold selectivity over BIKE (IC50 = 0.161 uM), and good kinase selectivity against in-house panel of kinases.
AAK1 inhibitor (S)-31 (30 mg/kg, sc) effectively reduced μ2 phosphorylation in C57BL6 mice.
AAK1 inhibitor (S)-31 exhibited improved enzyme and cellular potency compared to BMS-911172.

Physicochemical Properties

M.Wt	316.41
Formula	C20H20N4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(1-Amino-3-methylbutyl)-6-(pyridin-4-yl)quinoline-4-carbonitrile

References

1. Richard A Hartz, et al. J Med Chem. 2022 Mar 10;65(5):4121-4155.

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