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Chemical Structure : AAK1 inhibitor 25A
Catalog No.: PC-35961Not For Human Use, Lab Use Only.
AAK1 inhibitor 25A is a potent, selective inhibitor of AAK1 and the closely related kinase BMP2K with Ki of 8 nM (AAK1).
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AAK1 inhibitor 25A is a potent, selective inhibitor of AAK1 and the closely related kinase BMP2K with Ki of 8 nM (AAK1).
AAK1 inhibitor 25A displays selectivity over the other members of the subfamily, Numb-associated kinases GAK and STK16, in a TR-FRET binding displacement assay.
AAK1 inhibitor 25A binds to BMP2K in live HEK293T cells with an IC50 of 602 nM.
| M.Wt | 396.465 | |
| Formula | C20H20N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Agajanian MJ, et al. Cell Rep. 2019 Jan 2;26(1):79-93.e8.
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