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AAT-008

Chemical Structure : AAT-008

CAS No.: 847727-81-5

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AAT-008 (AAT008)

Catalog No.: PC-61499Not For Human Use, Lab Use Only.

AAT-008 is a potent, and selective prostaglandin EP4 receptor antagonist with binding IC50 of 2.4 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AAT-008 is a potent, and selective prostaglandin EP4 receptor antagonist with binding IC50 of 2.4 nM.
AAT-008 shows little or no activity for hEP1/2/3 (IC50>1890 nM).
AAT-008 inhibits PGE2-induced cAMP in human EP4 transfectant with pA2 of 8.97.
AAT-008 exhibits significantly improved pharmacological profiles over grapiprant in acute and chronic inflammatory pain models in rats.

Physicochemical Properties

M.Wt 414.817
Formula C21H16ClFN2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-[(1S)-1-[[[5-chloro-2-(3-fluorophenoxy)-3-pyridinyl]carbonyl]amino]ethyl]-benzoic acid

References

1. Okumura Y, et al. Bioorg Med Chem Lett. 2017 Mar 1;27(5):1186-1192.

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