Chemical Structure : AB-161
CAS No.:
2848560-66-5
AB-161
(AB161)
Catalog No.: PC-23459Not For Human Use, Lab Use Only.
AB-161 is a potent, selective and orally bioavailable PAPD5/7 inhibitor (IC50=0.85/1.1 uM) and HBV RNA destabilizer with EC50 of 2.2 nM for reduction of HBsAg in HepG2.2.15 cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AB-161 is a potent, selective and orally bioavailable PAPD5/7 inhibitor (IC50=0.85/1.1 uM) and HBV RNA destabilizer with EC50 of 2.2 nM for reduction of HBsAg in HepG2.2.15 cells.
AB-161 reduces HBsAg, HBeAg, and HBV DNA production with EC50 values ranging between 8.5 and 12 nM in primary human hepatocytes (PHH) infected with HBV.
AB-161 is inactive against a panel of ten RNA and DNA viruses (EC50 > 30 μM) displaying selectivity for HBV > 10,000-fold with no appreciable toxicity in cells derived from different tissues (CC50 > 30 μM).
AB-161 also inhibits multiple stages of the HBV life cycle including HBV pgRNA, preS/S RNA, HBV core and capsids, and replicating HBV DNA.
Physicochemical Properties
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M.Wt
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433.41
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Formula
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C21H21F2N3O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-5-(tert-Butyl)-11-(difluoromethoxy)-9-methoxy-2-oxo-1,2,5,6-tetrahydropyrido[2',1':2,3]imidazo[4,5- h]quinoline-3-carboxylic Acid
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References
1. Gotchev D, et al. J Med Chem. 2024 Nov 8. doi: 10.1021/acs.jmedchem.4c01928.
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