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Chemical Structure : AB-423
CAS No.: 1572510-80-5
Catalog No.: PC-63323Not For Human Use, Lab Use Only.
AB-423 is a novel potent, class II HBV capsid inhibitor that shows potent inhibition of HBV replication with EC50 of 0.08-0.27 uM, with no significant cytotoxicity (CC50>10 uM).
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|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $378 | In stock | |
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| 100 mg | Get quote |
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AB-423 (AB423) is a potent, class II HBV capsid inhibitor that shows potent inhibition of HBV replication with EC50 of 0.08-0.27 uM, with no significant cytotoxicity (CC50>10 uM).
AB-423 inhibits HBV genotypes A through D and nucleos/tide-resistant variants, causes capsid particles devoid of encapsidated pgRNA and rcDNA in treated HepDES19 cells.
AB-423 prevents the conversion of encapsidated rcDNA to cccDNA presumably by interfering with the capsid uncoating process.
AB-423 dose-dependently reduces serum HBV DNA levels in mouse model of HBV model, shows synergistic antiviral activity combined with entecavir (ETV).
| M.Wt | 386.389 | |
| Formula | C17H17F3N2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-5-(N-(sec-butyl)sulfamoyl)-N-(3,4-difluorophenyl)-2-fluorobenzamide |
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1. Mani N, et al. Antimicrob Agents Chemother. 2018 Mar 19. pii: AAC.00082-18.
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