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Chemical Structure : AB-506
Catalog No.: PC-72677Not For Human Use, Lab Use Only.
AB-506 is a small-molecule inhibitor targeting HBV core protein, inhibits viral replication in vitro (IC50=77 nM).
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AB-506 is a small-molecule inhibitor targeting HBV core protein, inhibits viral replication in vitro (IC50=77 nM).
AB-506 binds to HBV core protein, accelerates capsid assembly and inhibits HBV pgRNA encapsidation.
AB-506 blocks cccDNA establishment in HBV-infected HepG2-hNTCP-C4 cells and primary human hepatocytes, leading to inhibition of viral RNA, HBsAg, and HBeAg production (EC50=0.64-1.52 uM).
AB-506 demonstrated activity across HBV genotypes A-H and maintains antiviral activity against nucleostide analog-resistant variants in vitro.
AB-506 showed an 8 to 20-fold increase in EC50 values against L30F, L37Q, and I105T substitutions.
AB-506 exhibits good oral bioavailability, systemic exposure, and higher liver to plasma ratios in rodents.
| M.Wt | 461.854 | |
| Formula | C21H18ClF2N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nagraj Mani, et al. Antiviral Res. 2022 Jan;197:105211.
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