Chemical Structure : AB-836
CAS No.: 2445597-31-7
Catalog No.: PC-20678Not For Human Use, Lab Use Only.
AB-836 is a next generation oral hepatitis B virus (HBV) capsid inhibitor with HepDE19 EC50 of 10 nM, interacts with HBV core protein and demonstrates robust antiviral activity.
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AB-836 is a next generation oral hepatitis B virus (HBV) capsid inhibitor with HepDE19 EC50 of 10 nM, interacts with HBV core protein and demonstrates robust antiviral activity.
AB-836 in combination with nucleos(t)ide analogues is designed to completely eliminate viral replication in infected cells by preventing the assembly of functional viral capsids.
AB-836 has been shown to inhibit the replenishment of covalently closed circular DNA (cccDNA), the viral genetic reservoir which the virus needs to replicate itself.
M.Wt | 400.36 | |
Formula | C20H15F3N4O2 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
(R)-3-(3-cyano-4-fluorophenyl)-1-(1-(6,7-difluoro-1-oxo-1,2-dihydroisoquinolin-4-yl)ethyl)-1-methylurea |
1. Cole AG, et al. J Med Chem. 2024 Sep 4. doi: 10.1021/acs.jmedchem.4c01568.
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