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AB-836

Chemical Structure : AB-836

CAS No.: 2445597-31-7

AB-836 (AB836)

Catalog No.: PC-20678Not For Human Use, Lab Use Only.

AB-836 is a next generation oral hepatitis B virus (HBV) capsid inhibitor with HepDE19 EC50 of 10 nM, interacts with HBV core protein and demonstrates robust antiviral activity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AB-836 is a next generation oral hepatitis B virus (HBV) capsid inhibitor with HepDE19 EC50 of 10 nM, interacts with HBV core protein and demonstrates robust antiviral activity.
AB-836 in combination with nucleos(t)ide analogues is designed to completely eliminate viral replication in infected cells by preventing the assembly of functional viral capsids.
AB-836 has been shown to inhibit the replenishment of covalently closed circular DNA (cccDNA), the viral genetic reservoir which the virus needs to replicate itself.

Physicochemical Properties

M.Wt 400.36
Formula C20H15F3N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-3-(3-cyano-4-fluorophenyl)-1-(1-(6,7-difluoro-1-oxo-1,2-dihydroisoquinolin-4-yl)ethyl)-1-methylurea

References

1. Cole AG, et al. J Med Chem. 2024 Sep 4. doi: 10.1021/acs.jmedchem.4c01568.

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