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AB1

Chemical Structure : AB1

CAS No.: 1463912-49-3

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AB1 (AB-1;AB 1)

Catalog No.: PC-60746Not For Human Use, Lab Use Only.

AB1 is a potent, specific S1P2 receptor (Edg-5) antagonist with IC50 of 3 nM, with no agonistic or antagonistic activities on other S1PRs.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AB1 is a potent, specific S1P2 receptor (Edg-5) antagonist with IC50 of 3 nM, with no agonistic or antagonistic activities on other S1PRs.
AB1 is more effective than JTE-013 in blocking S1P2-mediated inhibition of cell migration in nuroblastoma, inhibits (C-C motif) ligand 2 expression and significantly inhibits subsequent tumor-associated macrophage infiltration in neuroblastoma xenografts.
AB1 induces apoptosis and shows antitumor activity in neuroblastoma models.

Physicochemical Properties

M.Wt 434.325
Formula C19H21Cl2N7O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(1H-4-isopropyl-1-allyl-3-methylpyrazolo[3,4-b]pyridine-6-yl)-amino-N'-(2,6-dichloropyridine-4-yl) urea

References

1. Li MH, et al. J Pharmacol Exp Ther. 2015 Sep;354(3):261-8.

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