ABBV-167 | BCL-2 inhibitor | Probechem Biochemicals

Chemical Structure : ABBV-167

ABBV-167 (ABBV167)

Catalog No.: PC-20511Not For Human Use, Lab Use Only.

ABBV-167 is a phosphate prodrug of the BCL-2 inhibitor venetoclax (Cat. PC-49764), shows significantly increased water solubility to venetoclax, demonstrates a lower food effect with respect to venetoclax.

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Biological Activity

Physicochemical Properties

M.Wt	978.45
Formula	C46H53ClN7O11PS
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(NS(=O)(C1=CC=C(NCC2CCOCC2)C([N+]([O-])=O)=C1)=O)C3=CC=C(N4CCN(CC5=C(C6=CC=C(Cl)C=C6)CC(C)(C)CC5)CC4)C=C3OC7=CN(COP(O)(O)=O)C8=NC=CC8=C7

References

1. Ahmed Hamed Salem, et al. Mol Cancer Ther. 2021 Jun;20(6):999-1008.

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ABBV-167 (ABBV167)

Biological Activity

Physicochemical Properties

References

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