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ABBV-167

Chemical Structure : ABBV-167

CAS No.: 1351456-78-4

ABBV-167 (ABBV167)

Catalog No.: PC-20511Not For Human Use, Lab Use Only.

ABBV-167 is a phosphate prodrug of the BCL-2 inhibitor venetoclax (Cat. PC-49764), shows significantly increased water solubility to venetoclax, demonstrates a lower food effect with respect to venetoclax.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ABBV-167 is a phosphate prodrug of the BCL-2 inhibitor venetoclax (Cat. PC-49764), shows significantly increased water solubility to venetoclax, demonstrates a lower food effect with respect to venetoclax.

    Physicochemical Properties

    M.Wt 978.45
    Formula C46H53ClN7O11PS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    O=C(NS(=O)(C1=CC=C(NCC2CCOCC2)C([N+]([O-])=O)=C1)=O)C3=CC=C(N4CCN(CC5=C(C6=CC=C(Cl)C=C6)CC(C)(C)CC5)CC4)C=C3OC7=CN(COP(O)(O)=O)C8=NC=CC8=C7

    References

    1. Ahmed Hamed Salem, et al. Mol Cancer Ther. 2021 Jun;20(6):999-1008.

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