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Chemical Structure : ABC99
CAS No.: 2331255-53-7
Catalog No.: PC-35279Not For Human Use, Lab Use Only.
ABC99 (NOTUM inhibitor ABC99) is a potent, selective inhibitor of the Wnt-deacylating enzyme serine hydrolase NOTUM with IC50 of 13 nM, shows excellent selectivity across the serine hydrolase family.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $228 | In stock | |
| 5 mg | $368 | In stock | |
| 10 mg | $558 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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ABC99 (NOTUM inhibitor ABC99) is a potent, selective inhibitor of the Wnt-deacylating enzyme serine hydrolase NOTUM with IC50 of 13 nM, shows excellent selectivity across the serine hydrolase family.
NOTUM inhibitor ABC99 preserves Wnt-mediated cell signaling in the presence of NOTUM in a concentration-dependent manner (IC50=89 nM) as measured using a Super TOPflash assay.
| M.Wt | 456.883 | |
| Formula | C22H21ClN4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
7-(4-chlorobenzyl)-1,3-dioxohexahydroimidazo[1,5-a]pyrazin-2(3H)-yl 2,3-dihydro-4H-benzo[b][1,4]oxazine-4-carboxylate |
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1. Suciu RM, et al. ACS Med Chem Lett. 2018 May 26;9(6):563-568.
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