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Chemical Structure : ABD-1970
Catalog No.: PC-35714Not For Human Use, Lab Use Only.
ABD-1970 (ABD1970) is a highly potent, selective Monoacylglycerol lipase (MAGL) inhibitor with IC50 of 13 nM (human MAGL).
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ABD-1970 (ABD1970) is a highly potent, selective Monoacylglycerol lipase (MAGL) inhibitor with IC50 of 13 nM (human MAGL).
ABD-1970 robustly elevated brain 2-AG content and displayed antinociceptive and anti-pruritic activity in a battery of rodent models (ED50 values of 1-2 mg/kg).
ABD-1970 also blocked 2-AG hydrolysis in human brain tissue and elevated 2-AG content in human blood without affecting stimulated prostanoid production.
| M.Wt | 515.881 | |
| Formula | C21H24ClF6N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Clapper JR, et al. J Pharmacol Exp Ther. 2018 Oct 10. pii: jpet.118.252296.
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