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Chemical Structure : ABD328
Catalog No.: PC-60550Not For Human Use, Lab Use Only.
ABD328 (ABD-328) is an orally active, small molecule inhibitor of RANKL and TNF signalling that inhibits inflammation in vivo.
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ABD328 (ABD-328) is an orally active, small molecule inhibitor of RANKL and TNF signalling that inhibits inflammation in vivo; inhibits TNF-induced activation of the NF-κB pathway, ERK, JNK and MAPKs in osteoclasts and macrophages, suppresses inflammatory arthritis, inhibits joint destruction and prevented systemic bone loss in mice model of rheumatoid arthritis.
| M.Wt | 337.24 | |
| Formula | C18H18Cl2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Coste E, et al. Ann Rheum Dis. 2015 Jan;74(1):220-6.
2. Idris AI, et al. Calcif Tissue Int. 2010 Dec;87(6):525-32.
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