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ABD328

Chemical Structure : ABD328

CAS No.: 1055896-19-9

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ABD328 (ABD-328, ABD 328)

Catalog No.: PC-60550Not For Human Use, Lab Use Only.

ABD328 (ABD-328) is an orally active, small molecule inhibitor of RANKL and TNF signalling that inhibits inflammation in vivo.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ABD328 (ABD-328) is an orally active, small molecule inhibitor of RANKL and TNF signalling that inhibits inflammation in vivo.
    ABD328 inhibits TNF-induced activation of the NF-κB pathway, ERK, JNK and MAPKs in osteoclasts and macrophages.
    ABD328 suppresses inflammatory arthritis, inhibits joint destruction and prevented systemic bone loss in mice model of rheumatoid arthritis.

    Physicochemical Properties

    M.Wt 337.24
    Formula C18H18Cl2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(2',4'-dichloro-[1,1'-biphenyl]-4-yl)-6-hydroxyhexan-1-one

    References

    1. Coste E, et al. Ann Rheum Dis. 2015 Jan;74(1):220-6.

    2. Idris AI, et al. Calcif Tissue Int. 2010 Dec;87(6):525-32.

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