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ABD345

Chemical Structure : ABD345

CAS No.: 1055896-51-9

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ABD345 (ABD-345, ABD 345)

Catalog No.: PC-63339Not For Human Use, Lab Use Only.

ABD345 is a small molecule inhibitor of RANKL signalling, inhibits TNF-induced NF-κB and MAPK activation and inflammation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ABD345 is a small molecule inhibitor of RANKL signalling, inhibits TNF-induced NF-κB and MAPK activation and inflammation.
    ABD345 inhibits osteoclast formation in mouse bone marrow cultures (IC50=1.7 uM) without any effects on bone marrow macrophage viability.
    ABD345 inhibits RANKL-induced phosphorylation of IκB and ERK in M-CSF-dependent bone marrow macrophage cultures.
    ABD345 inhibits both RANKL- and TNF-induced NF-κB and MAPK signalling in osteoclasts and macrophages, and inflammation and bone destruction in mouse model of rheumatoid arthritis.

    Physicochemical Properties

    M.Wt 318.364
    Formula C19H20F2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(2',4'-Difluoro-2-methyl[1,1'-biphenyl]-4-yl)-6-hydroxy-1-hexanone

    References

    1. Coste E, et al. Ann Rheum Dis. 2015 Jan;74(1):220-6.

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