Chemical Structure : ABD646
CAS No.:
ABD646
(ABD-646)
Catalog No.: PC-25365Not For Human Use, Lab Use Only.
ABD646 is a selective, covalent, small-molecule inhibitor of ABHD18, rescues TAFAZZIN (TAZ) mutant phenotypes in fibroblasts from human patients and in fish embryos.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ABD646 is a selective, covalent, small-molecule inhibitor of ABHD18, rescues TAFAZZIN (TAZ) mutant phenotypes in fibroblasts from human patients and in fish embryos.
ABD646 may bind to ABHD18(S199) covalently.
ABD646 shows a near-complete blockade of ABHD18 activity with modest selectivity at both 1 μM and 10 μM, as measured by the reduction of FP probe labelling.
ABD646 is also active in THP1 cells, as demonstrated by a roughly 80% inhibition of probe binding to ABHD18.
Chemical inhibition with ABD646 in cell culture matched the genetic inactivation of ABHD18.
ABD646 treatment (1 μM daily for 5 days) of zebrafish embryos largely restored heart morphology and function in Taz-deficient fish embryos.
Physicochemical Properties
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M.Wt
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428.38
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Formula
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C18H15F3N2O5S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-((4-(methylsulfonyl)benzyl)oxy)-3-(4-(trifluoromethyl)benzyl)-1,3,4-oxadiazol-2(3H)-one
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References
1. Masud SN, et al. Nature. 2025 Sep 3. doi: 10.1038/s41586-025-09373-5.
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