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ABD646

Chemical Structure : ABD646

CAS No.: 3094094-17-1

ABD646 (ABD-646)

Catalog No.: PC-25365Not For Human Use, Lab Use Only.

ABD646 is a selective, covalent, small-molecule inhibitor of ABHD18, rescues TAFAZZIN (TAZ) mutant phenotypes in fibroblasts from human patients and in fish embryos.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ABD646 is a selective, covalent, small-molecule inhibitor of ABHD18, rescues TAFAZZIN (TAZ) mutant phenotypes in fibroblasts from human patients and in fish embryos.
ABD646 may bind to ABHD18(S199) covalently.
ABD646 shows a near-complete blockade of ABHD18 activity with modest selectivity at both 1 μM and 10 μM, as measured by the reduction of FP probe labelling.
ABD646 is also active in THP1 cells, as demonstrated by a roughly 80% inhibition of probe binding to ABHD18.
Chemical inhibition with ABD646 in cell culture matched the genetic inactivation of ABHD18.
ABD646 treatment (1 μM daily for 5 days) of zebrafish embryos largely restored heart morphology and function in Taz-deficient fish embryos.

Physicochemical Properties

M.Wt 428.38
Formula C18H15F3N2O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-((4-(methylsulfonyl)benzyl)oxy)-3-(4-(trifluoromethyl)benzyl)-1,3,4-oxadiazol-2(3H)-one

References

1. Masud SN, et al. Nature. 2025 Sep 3. doi: 10.1038/s41586-025-09373-5.

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