ABH hydrochloride is a potent, selective human Arginase inhibitor with Ki of 0.25 uM (pH=7.5), 8.5 nM (pH=9.5) for type II arginase.
ABH hydrochloride inhibits the LPS-induced increases in pulmonary IL-8, neutrophils, and goblet cells as well as airway fibrosis.
ABH hydrochloride prevents LPS-induced right ventricular hypertrophy, indicative of pulmonary hypertension in a guinea pig model of COPD.
Physicochemical Properties
M.Wt
211.45
Formula
C6H14BNO4 · HCl
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(S)-2-amino-6-boronohexanoic acid hydrochloride
References
1. Colleluori DM, et al. Biochemistry. 2001 Aug 7;40(31):9356-62.
