ABRL8301 | 11β-HSD1 inhibitor | Probechem Biochemicals

Chemical Structure : ABRL8301

ABRL8301 (ABRL-8301)

Catalog No.: PC-27651Not For Human Use, Lab Use Only.

ABRL8301 is a 2-methoxyestradiol derivative that reduces 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) expression and increases heme oxygenase-1 (HO-1) levels in fibrosis-relevant cell types, shows anti-fibrotic efficacy, promoting mesenchymal-to-endothelial transition (MEndT) and reducing mesenchymal markers.

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Biological Activity

ABRL8301 is a 2-methoxyestradiol derivative that reduces 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) expression and increases heme oxygenase-1 (HO-1) levels in fibrosis-relevant cell types, shows anti-fibrotic efficacy, promoting mesenchymal-to-endothelial transition (MEndT) and reducing mesenchymal markers.
ABRL8301 inhibits NF-κB signaling in macrophages, promotes polarization toward the M2 anti-inflammatory phenotype, and suppresses interleukin-6 expression, contributing to its anti-fibrotic and immunomodulatory effects.
ABRL8301 significantly attenuated PPF in both bleomycin- and radiation-induced mouse models.
ABRL8301 also mitigated radiation-induced skin vascular injury and collagen accumulation.

Physicochemical Properties

M.Wt	582.73
Formula	C31H34O7S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(8R,9S,13S,14S,17S)-2-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diyl dibenzenesulfonate

References

1. Heo SW, et al. Eur J Pharmacol. 2026 Aug 11:179224.

ABRL8301 (ABRL-8301)

Biological Activity

Physicochemical Properties

References

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