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ABT-080

Chemical Structure : ABT-080

CAS No.: 189498-57-5

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ABT-080 (VML-530, ABT080)

Catalog No.: PC-35037Not For Human Use, Lab Use Only.

ABT-080 is a potent FLAP inhibitor that inhibits ionophore-stimulated LTB(4) formation with with IC50 of 20 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ABT-080 (VML-530) is a potent FLAP inhibitor that inhibits ionophore-stimulated LTB(4) formation with with IC50 of 20 nM.
ABT-080 selectively inhibits zymosan-stimulated mouse peritoneal macrophages producing LTC(4) with IC50 of 0.16 nM, 9000-fold selectivity over PGE(2) producing.
ABT-080 demonstrates leukotriene inhibition with oral dosing in a rat pleural inflammation model.

Physicochemical Properties

M.Wt 590.655
Formula C37H31N2NaO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4,4-Bis(4-(2-quinolylmethoxy)phenyl)pentanoic acid sodium salt

References

1. Kolasa T, et al. J Med Chem. 2000 Aug 24;43(17):3322-34.

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