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Chemical Structure : ABT-080
CAS No.: 189498-57-5
Catalog No.: PC-35037Not For Human Use, Lab Use Only.
ABT-080 is a potent FLAP inhibitor that inhibits ionophore-stimulated LTB(4) formation with with IC50 of 20 nM.
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|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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ABT-080 (VML-530) is a potent FLAP inhibitor that inhibits ionophore-stimulated LTB(4) formation with with IC50 of 20 nM.
ABT-080 selectively inhibits zymosan-stimulated mouse peritoneal macrophages producing LTC(4) with IC50 of 0.16 nM, 9000-fold selectivity over PGE(2) producing.
ABT-080 demonstrates leukotriene inhibition with oral dosing in a rat pleural inflammation model.
| M.Wt | 590.655 | |
| Formula | C37H31N2NaO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4,4-Bis(4-(2-quinolylmethoxy)phenyl)pentanoic acid sodium salt |
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1. Kolasa T, et al. J Med Chem. 2000 Aug 24;43(17):3322-34.
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