ABT-089 (Pozanicline) is a potent, selective α4β2 nAChR agonist with Ki of 16 nM; display selectivity over α7 nAChR (Ki>10 uM) and α1β1 nAChR.
ABT-089 displays a similar potency and efficacy to (-)-nicotine to facilitate ACh release (EC50=3 uM), with less potent and less efficacious stimulate dopamine release (ABT-089, EC50=1.1 uM; (-)-nicotine, EC50=0.04 uM).
ABT-089 shows effects on cognitive performance in rats and monkeys.
Physicochemical Properties
M.Wt
178.231
Formula
C11H16N2O
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-Methyl-3-[(2S)-pyrrolidinylmethoxy]pyridine
References
1. Lin NH, et al. J Med Chem. 1997 Jan 31;40(3):385-90.
