ABT-107 |CAS:855291-54-2 Probechem Biochemicals

Chemical Structure : ABT-107

ABT-107 (ABT107;ABT 107)

Catalog No.: PC-61621Not For Human Use, Lab Use Only.

ABT-107 is a potent and selective α7 nAChR agonist with Ki of 0.2-0.6 nM for rat or human cortex α7 nAChRs.

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Biological Activity

ABT-107 is a potent and selective α7 nAChR agonist with Ki of 0.2-0.6 nM for rat or human cortex α7 nAChRs; displays >100-fold selective versus non-α7 nAChRs and other receptors; potently evokes human and rat α7 nAChR current responses in oocytes (EC50=50-90 nM) enhanced by A-867744; reduces spinal tau hyperphosphorylation in tau/amyloid precursor protein transgenic AD mice; improves cognition in monkey.

Alzheimer Disease

Phase 2 Discontinued

Physicochemical Properties

M.Wt	320.39
Formula	C19H20N4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-[6-[[(3R)-1-azabicyclo[2.2.2]octan-3-yl]oxy]pyridazin-3-yl]-1H-indole

References

1. Malysz J, et al. J Pharmacol Exp Ther. 2010 Sep 1;334(3):863-74.

2. Bitner RS, et al. J Pharmacol Exp Ther. 2010 Sep 1;334(3):875-86.

3. Lee AM, et al. Behav Brain Res. 2014 Nov 1;274:168-75.

ABT-107 (ABT107;ABT 107)

Biological Activity

Physicochemical Properties

References

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