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Chemical Structure : ABT-107
Catalog No.: PC-61621Not For Human Use, Lab Use Only.
ABT-107 is a potent and selective α7 nAChR agonist with Ki of 0.2-0.6 nM for rat or human cortex α7 nAChRs.
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ABT-107 is a potent and selective α7 nAChR agonist with Ki of 0.2-0.6 nM for rat or human cortex α7 nAChRs; displays >100-fold selective versus non-α7 nAChRs and other receptors; potently evokes human and rat α7 nAChR current responses in oocytes (EC50=50-90 nM) enhanced by A-867744; reduces spinal tau hyperphosphorylation in tau/amyloid precursor protein transgenic AD mice; improves cognition in monkey.
Alzheimer Disease
Phase 2 Discontinued
| M.Wt | 320.39 | |
| Formula | C19H20N4O | |
| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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1. Malysz J, et al. J Pharmacol Exp Ther. 2010 Sep 1;334(3):863-74.
2. Bitner RS, et al. J Pharmacol Exp Ther. 2010 Sep 1;334(3):875-86.
3. Lee AM, et al. Behav Brain Res. 2014 Nov 1;274:168-75.
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