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ABT-239

Chemical Structure : ABT-239

CAS No.: 460746-46-7

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ABT-239 (ABT239, ABT 239)

Catalog No.: PC-42908Not For Human Use, Lab Use Only.

ABT-239 is a potent and selective Histamine H3 receptor antagonist with Ki of 0.1-5.8 nM (human, rat H3).

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5 mg $98 In stock
10 mg $158 In stock
25 mg $278 In stock
50 mg $478 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ABT-239 is a potent and selective Histamine H3 receptor antagonist with Ki of 0.1-5.8 nM (human, rat H3).
ABT-239 exhibits 1000-fold selectivity versus H1, H2 and H4.
ABT-239 exhibits excellent pharmacokinetic and metabolic properties across species and good oral bioavailability.

Physicochemical Properties

M.Wt 330.4229
Formula C22H22N2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 3.3 mg/mL
Chemical Name/SMILES

Benzonitrile, 4-[2-[2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl]-5-benzofuranyl]-

References

1. Cowart M, et al. J Med Chem. 2005 Jan 13;48(1):38-55.

2. Esbenshade TA, et al. J Pharmacol Exp Ther. 2005 Apr;313(1):165-75.

3. Bhowmik M, et al. Brain Res. 2014 Sep 18;1581:129-40.

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