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Chemical Structure : ABT-288
CAS No.: 948845-91-8
Catalog No.: PC-63032Not For Human Use, Lab Use Only.
ABT-288 is a potent, selective and competitive antagonist of H3 receptor with Ki of 1.9/8.2 nM for human/rat H3 respectively.
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|---|---|---|---|
| 5 mg | $298 | In stock | |
| 10 mg | $478 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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ABT-288 is a potent, selective and competitive antagonist of H3 receptor with Ki of 1.9/8.2 nM for human/rat H3 respectively.
ABT-288 enhances the release of acetylcholine and dopamine in rat prefrontal cortex.
ABT-288 possesses excellent pharmacokinetics and oral bioavailability.
| M.Wt | 372.472 | |
| Formula | C23H24N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-[4'-((3aR,6aR)-5-methyl-hexahydro-pyrrolo[3,4-b]pyrrol-1-yl)-biphenyl-4-yl]-2H-pyridazin-3-one |
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1. Esbenshade TA, et al. J Pharmacol Exp Ther. 2012 Oct;343(1):233-45.
2. Hudzik TJ, et al. Psychopharmacology (Berl). 2013 Jul;228(2):187-97.
3. Othman AA, et al. Br J Clin Pharmacol. 2014 Jun;77(6):965-74.
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