Chemical Structure : ABT-418
CAS No.:
147402-53-7
ABT-418
(ABT418)
Catalog No.: PC-20544Not For Human Use, Lab Use Only.
ABT-418 (ABT418) is an analog of (-)-nicotine and cholinergic ligand (activator) of nAChRs, a potent inhibitor of [3H]-cytisine binding to nAChR in rat brain with Ki of 2 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ABT-418 (ABT418) is an analog of (-)-nicotine and cholinergic ligand (activator) of nAChRs, a potent inhibitor of [3H]-cytisine binding to nAChR in rat brain with Ki of 2 nM.
ABT-418 is inactive (Ki > 10,000 nM) in 37 other receptor/neurotransmitter-uptake/enzyme/transduction system binding assays.
ABT-418 is also approximately 10-fold less potent (EC50 value=380 nM) than (-)-nicotine (40 nM) in increasing [3H]-dopamine release from rat striatal slices.
ABT-418 (MED, 0.002 mumol/kg i.v.) is remarkably potent in enhancing basal forebrain-elicited increases in cortical cerebral blood flow in rats.
ABT-418 demonstrates potent cognitive-enhancing and anxiolytic properties in animal models without eliciting significant side effects.
Physicochemical Properties
|
M.Wt
|
166.22
|
|
Formula
|
C9H14N2O
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
CN1[C@H](C2=CC(C)=NO2)CCC1
|
References
1. Arneric SP, et al. J Pharmacol Exp Ther. 1994 Jul;270(1):310-8.
2. Decker MW, et al. J Pharmacol Exp Ther. 1994 Jul;270(1):319-28.
Contact Us
sales@probechem.com
