Chemical Structure : ABT-418 hydrochloride
CAS No.:
147388-83-8
ABT-418 hydrochloride
Catalog No.: PC-20545Not For Human Use, Lab Use Only.
ABT-418 hydrochloride (ABT418) is an analog of (-)-nicotine and cholinergic ligand (activator) of nAChRs, a potent inhibitor of [3H]-cytisine binding to nAChR in rat brain with Ki of 2 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ABT-418 hydrochloride (ABT418) is an analog of (-)-nicotine and cholinergic ligand (activator) of nAChRs, a potent inhibitor of [3H]-cytisine binding to nAChR in rat brain with Ki of 2 nM.
ABT-418 is inactive (Ki > 10,000 nM) in 37 other receptor/neurotransmitter-uptake/enzyme/transduction system binding assays.
ABT-418 is also approximately 10-fold less potent (EC50 value=380 nM) than (-)-nicotine (40 nM) in increasing [3H]-dopamine release from rat striatal slices.
ABT-418 (MED, 0.002 mumol/kg i.v.) is remarkably potent in enhancing basal forebrain-elicited increases in cortical cerebral blood flow in rats.
ABT-418 demonstrates potent cognitive-enhancing and anxiolytic properties in animal models without eliciting significant side effects.
Physicochemical Properties
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M.Wt
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202.68
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Formula
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C9H15ClN2O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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CN1[C@H](C2=CC(C)=NO2)CCC1.[H]Cl
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References
1. Arneric SP, et al. J Pharmacol Exp Ther. 1994 Jul;270(1):310-8.
2. Decker MW, et al. J Pharmacol Exp Ther. 1994 Jul;270(1):319-28.
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