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ABT-546

Chemical Structure : ABT-546

CAS No.: 212481-66-8

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ABT-546 (A-216546)

Catalog No.: PC-20050Not For Human Use, Lab Use Only.

ABT-546 (A-216546) is a potent, selective, small-molecule antagonist of ETA endothelin receptor with IC50 of 0.49 nM, shows high selectivity over ETB receptor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ABT-546 (A-216546) is a potent, selective, small-molecule antagonist of ETA endothelin receptor with IC50 of 0.49 nM, shows high selectivity over ETB receptor.
    ABT-546 effectively inhibits specific I endothelin-1 binding to endothelin ETA receptor in membrane prepared from rat pituitary MMQ cells with IC50 of 0.56 nM.
    ABT-546 blocks endothelin-1-induced arachidonic acid release and phosphatidylinositol hydrolysis with IC50 of 0.59 nM and 3 nM, respectively.

    Physicochemical Properties

    M.Wt 532.72
    Formula C30H48N2O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2S,3R,4S)-1-[2-(Dibutylamino)-2-oxoethyl]-2-(2,2-dimethylpentyl)-4-(7-methoxy-1,3-benzodioxol-5-yl)-3-pyrrolidinecarboxylic acid

    References

    1. Wessale JL, et al. Clin Sci (Lond). 2002 Aug;103 Suppl 48:112S-117S.

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