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ABT-702 dihydrochloride

Chemical Structure : ABT-702 dihydrochloride

CAS No.: 1188890-28-9

ABT-702 dihydrochloride (ABT702)

Catalog No.: PC-38791Not For Human Use, Lab Use Only.

ABT-702 is a potent, selective, orally active, non-nucleoside adenosine kinase (ADK) inhibitor with IC50 of 1.7 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ABT-702 is a potent, selective, orally active, non-nucleoside adenosine kinase (ADK) inhibitor with IC50 of 1.7 nM.
ABT-702 displays several orders of magnitude selectivity over other sites of ADO interaction (A(1), A(2A), A(3) receptors, ADO transporter, and ADO deaminase), and 1300- to 7700-fold selective for ADK compared with a number of other neurotransmitter and peptide receptors, ion channel proteins, neurotransmitter/nucleoside reuptake sites, and enzymes, including COX-1 and -2.
ABT-702 is orally active and fully efficacious in reducing acute somatic nociception (ED50 = 8 micromol/kg i.p.; 65 micromol/kg p.o.) in the mouse hot-plate assay.
ABT-702 also dose dependently reduced nociception in the phenyl-p-quinone-induced abdominal constriction assay.
ABT-702 dispalyed analgesic and anti-inflammatory properties in vivo.

Physicochemical Properties

M.Wt 536.25
Formula C22H21BrCl2N6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2,3-d]pyrimidin-4-amine dihydrochloride

References

1. Kowaluk EA, et al. J Pharmacol Exp Ther. 2000 Dec;295(3):1165-74.

2. Lee CH, et al. J Med Chem. 2001 Jun 21;44(13):2133-8.

3. Suzuki R, et al. Br J Pharmacol. 2001 Apr;132(7):1615-23. al.

4. Jarvis MF, et al. J Pharmacol Exp Ther. 2000 Dec;295(3):1156-64.

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