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Chemical Structure : ABT 089 dihydrochloride
CAS No.: 161416-61-1
Catalog No.: PC-61620Not For Human Use, Lab Use Only.
ABT 089 dihydrochloride (Pozanicline) is a potent and selective α4β2 nAChR agonist with Ki of 16 nM; display selectivity over α7 nAChR (Ki>10 uM) and α1β1 nAChR.
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| 100 mg | $498 | In stock | |
| 200 mg | $758 | In stock | |
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ABT 089 dihydrochloride (Pozanicline) is a potent and selective α4β2 nAChR agonist with Ki of 16 nM; display selectivity over α7 nAChR (Ki>10 uM) and α1β1 nAChR.
ABT 089 displays a similar potency and efficacy to (-)-nicotine to facilitate ACh release (EC50=3 uM), with less potent and less efficacious stimulate dopamine release (ABT-089, EC50=1.1 uM; (-)-nicotine, EC50=0.04 uM).
ABT 089 shows effects on cognitive performance in rats and monkeys.
| M.Wt | 265.18 | |
| Formula | C11H16N2O.2HCl | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-Methyl-3-[(2S)-pyrrolidinylmethoxy]pyridine dihydrochloride |
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1. Lin NH, et al. J Med Chem. 1997 Jan 31;40(3):385-90.
2. Sullivan JP, et al. J Pharmacol Exp Ther. 1997 Oct;283(1):235-46.
3. Decker MW, et al. J Pharmacol Exp Ther. 1997 Oct;283(1):247-58.
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