Catalog No.: PC-35551Not For Human Use, Lab Use Only.
ABX-1431 (Elcubragistat) hydrochloride is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MAGL) with IC50 of 14 nM (hMAGL).
ABX-1431 (Elcubragistat) hydrochloride is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MAGL) with IC50 of 14 nM (hMAGL).
ABX-1431 displays 23-fold selectivity for MGLL versus ABHD6 and CES1c, as well as exquisite selectivity of against other members of the serine hydrolase class.
ABX-1431 inhibits MGLL activity in rodent brain (ED50=0.5-1.4 mg/kg), increases brain 2-AG concentrations, and suppresses pain behavior in the rat formalin pain model.
