Catalog No.: PC-36055Not For Human Use, Lab Use Only.
Obefazimod (ABX464) is a novel class of anti-HIV small molecule targeting Rev-mediated viral RNA biogenesis, shows dose dependent inhibition of HIV-1 replication in stimulated PBMCs with IC50 of 0.1-0.5 uM.
Obefazimod (ABX464) is a novel class of anti-HIV small molecule targeting Rev-mediated viral RNA biogenesis, shows dose dependent inhibition of HIV-1 replication in stimulated PBMCs with IC50 of 0.1-0.5 uM.
ABX464 inhibits different HIV-1 clades, resistant viruses and did not select for resistance.
ABX464 increases the levels of spliced HIV RNA, influences REV-mediated HIV RNA biogenesis and export, and interacts with the CBC complex.
ABX464 inhibits viral replication in humanized mice.
