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Chemical Structure : ABX464
CAS No.: 1258453-75-6
Catalog No.: PC-36055Not For Human Use, Lab Use Only.
Obefazimod (ABX464) is a novel class of anti-HIV small molecule targeting Rev-mediated viral RNA biogenesis, shows dose dependent inhibition of HIV-1 replication in stimulated PBMCs with IC50 of 0.1-0.5 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $348 | In stock | |
| 100 mg | $798 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Obefazimod (ABX464) is a novel class of anti-HIV small molecule targeting Rev-mediated viral RNA biogenesis, shows dose dependent inhibition of HIV-1 replication in stimulated PBMCs with IC50 of 0.1-0.5 uM.
ABX464 inhibits different HIV-1 clades, resistant viruses and did not select for resistance.
ABX464 increases the levels of spliced HIV RNA, influences REV-mediated HIV RNA biogenesis and export, and interacts with the CBC complex.
ABX464 inhibits viral replication in humanized mice.
| M.Wt | 338.714 | |
| Formula | C16H10ClF3N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
8-chloro-N-(4-(trifluoromethoxy)phenyl)quinolin-2-amine |
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1. Campos N, et al. Retrovirology. 2015 Apr 9;12:30.
2. Scherrer D, et al. Antimicrob Agents Chemother. 2016 Dec 27;61(1).
3. Scherrer D, et al. J Antimicrob Chemother. 2017 Mar 1;72(3):820-828.
4. Vautrin A, et al. Sci Rep. 2019 Jan 28;9(1):792.
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